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The enzyme cyp2d6 affects the metabolism of many drugs, and its effect is altered by genetic variability. It is accepted that strong inhibitors result in nearly null enzymatic activity, but reduction caused by moderate and weak inhibitors. In this issue, we will discuss cyp2d6?an enzyme that is involved in the metabolism of numerous drugs
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Cyp2d6 also is involved in the activation of some drugs, so these drugs may have reduced efficacy when patients with inadequate cyp2d6 activity take them. The fda lists 22 medications as clinical inhibitors of cyp2d6, with classifications of strong, moderate, and weak In this article i highlight my list of drugs that inhibit cyp2d6 and also share some case examples from my clinical pharmacy practice.
Importantly, altered cyp2d6 function has been associated with both adverse drug reactions and reduced drug efficacy, and there is growing recognition of the clinical and economic burdens associated with suboptimal drug utilisation.
In previous issues of pharmacy times we have discussed the cytochrome p450 (cyp450) enzymes cyp1a2, cyp2c9, and cyp2c19 In this issue, we will discuss cyp2d6—an enzyme that is involved in the metabolism of numer ous drugs. A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (mdd), seasonal affective disorder (sad), and as an aid to smoking cessation A calcium sensing receptor agonist used to treat secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in parathyroid carcinoma.
For patients receiving (or about to receive) tamoxifen, screen their current medications carefully for drugs that inhibit cyp2d6 The table would be a good start, but these lists change over time with new research and new drugs on the market Consult a current list to find cyp2d6 inhibitors. Cyp2d6 is a cytochrome p450 (cyp) enzyme involved in the metabolism of any medications that are cyp2d6 substrates, which includes many commonly used medications
Cyp2d6 inhibitors can reduce the body’s metabolism of these medications.
