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A minority of transfusion services have protocols for prophylactic transfusion with extended rbc matching beyond c, e and k that could further reduce the alloimmunization risk. In light of the increasing amount of evidence supporting low rbc alloimmunization rates, transfusion medicine services should reevaluate their protocols for patients starting and receiving treatment with daratumumab. We subsequently compared the pattern of rbc alloantibodies between the two groups and assessed the impact of alloimmunization on rbc autoantibody formation and rbc transfusion burden

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Extended rh and k rbc phenotype was available for 450 myeloid neoplasm (mn) patients. To examine the limitations of the evidence, we undertook a systematic review of evidence behind recommendations for limited and extended serologic and genotypic rbc antigen matching to reduce alloimmunization, autoimmunization and transfusion reactions. The aim of this study was to evaluate the benefit of rbc transfusion with extended antigenic match.