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This document provides recommendations for reversing anticoagulants in patients with bleeding complications Background andexanet alfa is approved (fda accelerated approval It compares different reversal agents, including pcc (kcentra®), and their mechanisms, onset, duration, and notes.
ANDEXXA – BioCare, Inc.
Kcentra and andexxa are both reasonable options for factor xa reversal in major bleeding This study aims to compare the efficacy and outcomes of andexanet alfa and kcentra for reversal of apixaban or rivaroxaban in bleeding or surgical patients While andexxa appears to have good hemostatic efficacy, it has greater risk of thrombotic events, specifically cerebrovascular events, compared to kcentra, and no differences in mortality.
Patients with acute intracerebral hemorrhage who are receiving factor xa inhibitors have a risk of hematoma expansion
The effect of andexanet alfa, an agent that reverses the effects of factor xa. Unlike kcentra, does not include any endogenous anticoagulants This gives factor ix complex a greater tendency to promote thrombosis However, it is probably riskier and is supported by less evidence, when compared to kcentra.
It was approved by the fda in may 2018 and became commercially available in the first quarter of 2019.
