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Robin holliday proposed the junction structure that now bears his name as part of his model of homologous recombination in 1964, based on his research on the organisms ustilago maydis and saccharomyces cerevisiae. Explore the structure, function, and biophysical properties of holliday junctions, key to genetic recombination, dna repair, and the future of genetic engineering. Holliday structure, the most important intermediate in recombination is also known as holliday junction or half chiasma
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The first molecular model of the genetic exchange that occurs between homologous chromosomes during recombination was proposed by robert holliday. The recombinant joint proposed by holliday has been visualized in electron micrographs of recombining dna duplexes (figure 8.7a). Introduces the holliday model, discovered in 1964, which explains genetic recombination processes
Defines duplex and heteroduplex dna structures important for genetic recombination
Outlines the sequential steps in the holliday model including alignment, nick formation, and resolution. This shows the steps in the holliday model in a movie, illustrating the actions much more vividly than static diagrams
